Interleukin-1 receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the IRAK1 gene. IRAK-1 plays an important role in the regulation of the expression of inflammatory genes by immune cells, such as monocytes and macrophages, which in turn help the immune system in eliminating bacteria, viruses, and other pathogens. IRAK-1 is part of the IRAK family consisting of IRAK-1, IRAK-2, IRAK-3, and IRAK-4, and is activated by inflammatory molecules released by signaling pathways during pathogenic attack. IRAK-1 is classified as a kinase enzyme, which regulates pathways in both innate and adaptive immune systems.
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{"slip": { "id": 139, "advice": "If you're going bald, don't comb your hair over your bald patch."}}
{"slip": { "id": 44, "advice": "If you are feeling down, try holding a pencil between your top lip and your nose for five minutes."}}
{"fact":"A cat's whiskers are thought to be a kind of radar, which helps a cat gauge the space it intends to walk through.","length":113}
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{"type":"general","setup":"What do you get when you cross a bee and a sheep?","punchline":"A bah-humbug.","id":229}